In addition, OCTA metrics of the retinal vasculature allows investigating the correlation of these findings with microvascular damage in other organs such as the kidney or the previous glycemic control 6, 7, 8. The quantification of the rich granular data provided by OCTA images has made it possible to expand a further field of research allegedly called OCTA angyolitics 5. In diabetic retinopathy, OCTA has helped to document disease progression and to assess risk stratification by providing two-dimensional capillary perfusion density maps for the quantification of the superficial and deep capillary layers. Therefore, OCTA enables the reconstruction of retinal microvascular flow maps, as a beneficial imaging tool in a series of microvascular pathologies, such as diabetic retinopathy 3, 4. Optical coherence tomography angiography (OCTA) is an imaging technique that uses the variation in signal intensity caused by moving blood particles, such as erythrocytes, as the contrast mechanism for the visualization of functional blood vessels in the eye 1, 2. It offers novel insights into the characterization of normal retinal vascular anatomy in healthy individuals, contributing to a valuable reference for future research in this field. This is the first study to assess 3D OCTA VV and its naturally occurring variations in a large series of healthy subjects. No statistically significant associations were identified between gender or between left and right eyes. However, GLM model analysis found that AL exerted the most pronounced influence on VV. Age and axial length showed a negative correlation with VV. Generalized linear models (GLM) were constructed to assess the impact of age, gender, visual acuity (VA), spherical equivalent (SE), and axial length (AL) on VV. In this study, OCTA 3 × 3 mm macular cubes were processed with volume-rendering techniques to measure VV in 203 eyes from 107 healthy volunteers. In spite of the widespread use of OCTA, no representative volume-rendered vessel volume (VV) data are published to date. Therefore, it enables the quantification of 3D retinal vessel parameters such as surface area and vessel volume. Optical coherence tomography angiography (OCTA) enables three-dimensional reconstruction of the functional blood vessels in the retina.
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